you can connect to the file with sql and run your analysis from there.
i have written extremely detailed r code (r is free and open source) about how to work with the nppes from your laptop here:
http://www.asdfree.com/search/label/national%20plan%20and%20provider%20enumeration%20system%20%28nppes%29http://asdfree.com/national-plan-and-provider-enumeration-system-nppes.html
if you have never used r before, check out http://twotorials.com for a crash course
hope this helps :)